Smad-interacting protein 1 affects acute and tonic, but not chronic pain
نویسندگان
چکیده
منابع مشابه
The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability.
The perception of pain is initiated by the transduction of noxious stimuli through specialized ion channels and receptors expressed by primary nociceptive neurons. The molecular mechanisms that orchestrate the expression and function of ion channels relevant for pain processing are poorly understood. We demonstrate here a central role of the transcription factor Smad-interacting protein 1 (Sip1...
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Protein interacting with C Kinase 1 (PICK1), a PDZ domain-containing scaffolding protein, interacts with multiple different proteins in the mammalian nervous system and is believed to play important roles in diverse physiological and pathological conditions. In this study, we report that PICK1 is expressed in neurons of the dorsal root ganglion (DRG) and spinal cord dorsal horn, two major pain-...
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ژورنال
عنوان ژورنال: European Journal of Pain
سال: 2013
ISSN: 1090-3801
DOI: 10.1002/j.1532-2149.2013.00366.x